Value of AgNOR, in Malignant Lesions of Cervix

AUTHOR(s) : Sonowal Basanta, Handique Amitabh
DOI No. : 09.2016-41461927

Objectives: To evaluate the correlation of AgNOR count and malignant lesions of cervix. Methods: The material for the study was collected from patient with various lesions of cervix. After colposcopy, a cervical biopsy was done. Routine paraffin sectioning was done for these biopsy specimens. Histopathologic diagnosis was first established on these sections using the routine (H & E) stain. Then, further sections were cut from prepared blocks and were subjected to AgNOR staining technique. AgNOR count was taken as the mean number of black dots per 100 cells observed under a 100× oil immersion objective. Results: In this series biopsy specimens were obtained and subjected to routine method of haematxoylin and eosin staining which revealed 25% to be benign and 26.6% to be cervical intraepithelial neoplasia and 48.4% cases to be carcinoma. Conclusion: The results of the AgNOR when used can provide strength to the clinician and histopathologist in diagnosing early carcinoma in cases of suspicious cervix.

Registered Office Address:
House No: One, Karmabir Bordoloi Path, Wireless,
Rukmini Nagar, Dispur-06, Assam, India

Mobile: 09435017802
IJHRMLP is an open-access journal, and the articles published are instantly available to read and use again. The published articles thus can be downloaded, shared, and reused without restriction if the contributing original authors are appropriately cited. Author(s) retain the copyright of their article, with articles licensed to AHRME and the journal following the Creative Commons Attribution License (CC-BY).
Maintain By Prism Infosys