A clinical study of non-alcoholic Fatty Liver disease in Type 2 Diabetes Mellitus

AUTHOR(s) : Bhattacharyya Dipen Kumar, Choudhury Bikash Narayan, Bharadwaj Sanjeeb, Das Madhumita Priyadarshini
DOI No. : 01.2017-45399793

ABSTRACT :
Background: Non-alcoholic fatty liver disease (NAFLD) is no longer considered a benign condition and has been identified as a common cause of chronic liver disease globally. Methods: This study was done on 199 cases of Type 2 Diabetes Mellitus with proper history, thorough clinical examination, including exact height, weight with relevant investigations. Results: The prevalence was 65.8%. Evidence of NAFLD was noted in 59.15% of male and 82.45% of female. Most of the cases were asymptomatic and hepatomegaly was the only commonest physical sign. 83.47% participants with high BMI were found to have NAFLD. The mean of fasting, post-prandial glucose levels and that of HbA1 C in NAFLD, were significantly higher as compared to that with normal liver. The mean AST, ALT and ALKP levels were significantly higher as compared to the normal liver group. The ratio between AST and ALT was found to be 0.96. The mean of the total cholesterol, triglycerides and LDL were found significantly higher in the group with NAFLD, while difference in the mean value of HDL in both the groups were insignificant. Conclusion: NAFLD is more frequently encountered in poorly controlled Diabetes Mellitus, more so in presence of obesity and/or dyslipidaemia.

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