Role of KIR gene cluster in susceptibility to rheumatoid arthritis

AUTHOR(s) : Kakati Pankaj, Misra Dhritiman, Choudhury MK, Talukdar KL, Deka Roonmoni, Baruah Chitralekha
DOI No. : 10.31741/ijhrmlp.v5.i2.2019.9

ABSTRACT :
Rheumatoid Arthritis (RA) is an autoimmune and chronic in√Ľammatory disease of unknown etiology whose pathogenesis is not fully understood. Small joints in the hands and feet are involved the most. Genetic risk association of RA with HLA-DRB1 gene is the most significant. Women are more affected than men. Natural killer cells and CD28 null T-cells present in synovial membranes of joints of RA patients express Killer cell immunoglobulin-like receptors on its surface. KIR gene cluster has a strong association with autoimmunity as found in various studies. Objective: To investigate the role of various genes of KIR gene cluster in the pathogenesis of RA. Materials and methods: Blood samples from 80 cases (following ACR/ EULAR criteria- 2010) and 80 controls were collected in EDTA vials using standard venipunture procedure. DNA was extracted from each of the collected blood samples and KIR genotyping was done by molecular techniques using SSP kits. Results: The presence of KIR2DS1, KIR2DS3, KIR2DS4, KIR2DS5 and KIR3DL1 genes among RA patients showed risk association. Using standard statistical tools results were validated. Conclusion: Some of the KIR genes have risk association with occurrence of RA. Individuals carrying these genes are suspected to be more susceptible to develop RA.

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